They typically include a summary of the case, teaching objectives, information about the intended audience, details about how the case may be taught, and a list of references and resources. How can you reconcile this observation with the cause of death being hypoxia? To understand, we need to take a very close look at the structure of the mitochondrion. Part I introduces the case and gets students to think epidemiologically about the information they receive. Cyanide acts very quickly, often killing within minutes of ingestion and authorities were slow to identify the cause of the deaths.
I love this case study and my students really enjoy it. Her parents said that she was awake in the middle of the night complaining of a stuffy nose and sore throat. Once the cause as identified, stores removed tylenol and other drugs from shelves. Oxygen then binds with proteins to create water. It is your job to examine the data and determine the cause of death for these victims.
Why is the mitochondrion important?
JCST – May/June 2014
Return to the homepage. Cyanide acts respirtaion quickly, often killing within minutes of ingestion and authorities were slow to identify the cause of the deaths. Are there any similarities or connections between these seven individuals? Were the levels higher or lower than normal?
On further investigation, it was shown that the tissues had major mitochondrial damage. The proteins in the membrane pass electrons from one to the other, this is known as the electron transport chain. On further investigation, it was shown that the tissues had major mitochondrial damage. This discussion can be omitted if time is limited. Symptoms exhibited by each of the victims included: Most students quickly recognize that the oxygen levels in the blood do not correspond with hypoxia as the cause of death.
Toxicology reports show chiczgo the victims had been poisoned with cyanide. They gave her an extra strength Tylenol and sent her back to bed. This is one of the best case studies I’ve used so far. While poison is the main suspect in the case, what are other ways a person could die of hypoxia? You might be surprised to learn that it directly interferes with cellular respiration that occurs in the mitochondria.
This case has four sections, or parts. Criminal incidents, in contrast, involve extortion, murder, or some other nonpolitical objective.
Chicago Cyanide Murders: A Case Study in Cellular Respiration
At 7 am the next morning, her daughter was found collapsed on the bathroom floor, and later pronounced dead. My AP Biology students were engaged throughout the entire activity and really enjoyed taking on the role of medical examiner. An ambulance rushed the girl to a nearby hospital, where she was pronounced dead.
The medical examiner also showed the tissue samples from the heart, lungs, and liver showed massive cell death. In your cellullar, are the seven deaths connected?
Hypoxia means that the person suffered from a lack of oxygen, or they were suffocated. This case is based loosely on the real-life Chicago Tylenol murders in which seven people died from cyanide poisoning, which interrupts the function of the electron transport chain ETC.
What additional information would you need to determine if they are connected? Given what you now know about the action of cyanide on cellular respiration, explain why the patients died of lack of oxygen while their blood oxygen levels were normal. Place an X over the protein that is inhibited by cyanide.
This process is continuous in cells, with ATP constantly being generated and oxygen being used as the final electron acceptor. Looking back at the information you have about the people before they got sick, can you suggest a possible source of the cyanide poisoning?
The Mystery of the Seven Deaths – National Center for Case Study Teaching in Science
Adam Janus, a postal worker in another Chicago suburb also died unexpectedly, though originally it was thought he had suffered from a heart attack. The test of all seven patients came back positive for cyanide. Why or why not?
Adam Janus, a postal worker in another Chicago suburb also died unexpectedly, though originally it was thought he had suffered from a heart attack.
Both had taken Tylenol to help them cope with their loss shortly before collapsing; neither survived. This observation piques their interest to investigate further.
What does this mean?