DISSERTATION HUBERT PAUSCH

Genome-wide distribution of the proportion of correctly imputed genotypes. Recent human effective population size estimated from linkage disequilibrium. A Case Study in Dairy Cattle. Genotype imputation allows to combine different datasets and to infer missing genotypes in silico [25]. Re- sequencing a small number of key animals enables to assess a large fraction of the global genomic variation of livestock populations [2],[3]. Sample size required to identify a QTL for traits with different heritability.

An important prerequisite for unbiased QTL mapping based on linkage disequilibrium LD is homogeneity of the mapping population [11]. Diffusion- and functional MRI are promising avenues for revealing functional organization in the living human brain since they provide noninvasive measurements pertaining to the anatomy of cortical connectivity and the physiology of brain activity. The proportion of phenotypic variation attributable to a particular chromosome was then estimated with the effects of all chromosomes fitted simultaneously. The results of the present thesis demonstrate that a few loci with large effects and thus detectable by GWAS exist for each of the analysed traits in the FV population, which agrees with previous findings e. The distribution of loci with large effects is a major issue for the the appropriate model selection for genomic prediction in cattle populations. Associations in validation populations might be biased when the used phenotypes differ only slightly [94].

The characteristics of the significantly associated SNPs are listed in Table 1. However, the Ne decreased considerably within the last generations. Genome-wide association study A genome-wide association study was pahsch using a variance components based approach to account for population stratification and to eliminate the resulting inflation of false positive associations.

The aim of the present study was to gain insights into the genetic architecture of a special aspect of skin pigmentation and to provide the basis for more efficient selection for animals that are less susceptible to serious eye diseases.

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Pausch, Hubert, Prof. Dr. | ETH Zurich

Forni S, Aguilar I, Misztal I Different genomic relationship matrices for single-step analysis using phenotypic, pedigree and genomic information. The linear relationship between chromosome length and its contribution to the genetic variation seems to be more prominent in production traits [18],[19].

Performance of bovine high-density genotyping platforms in Holsteins and Jerseys. Dematawewa CM, Berger PJ Effect of dystocia on yield, fertility, and cow losses and an economic evaluation of dystocia scores for Holsteins. This issue is especially apparent considering breeding values for eissertation traits, where evaluation models differ substantially among cattle breeds [5].

dissertation hubert pausch

The proportion of daughters with ACOP is a progeny-derived phenotype for the bulls and acts therefore purely additively. The identification of the underlying QTN is further complicated by the fact that several adjacent markers with small effects might form a composite QTL [36]. Calving traits are complex as they are influenced by sire-effects through the size of the calf as well as by dam-effects consisting mainly of the pelvic dimensions. The remaining samples exhibited an average genotyping rate of Additional information List of publications at Google Scholar.

However it explains less of the genetic variance than the most significant SNP does Summary Summary The development of dissertqtion single nucleotide polymorphisms SNP panels enables to interrogate genotypes for a large number of polymorphic sites simultaneously. The grey shaded bars indicate the fraction of DYD variance attributed to a particular chromosome and the corresponding standard error.

Nucleic Acids Research An animal of the disxertation Fleckvieh breed with ambilateral circumocular pigmentation. The proportion of phenotypic variation attributable to a particular chromosome was then estimated with the effects of all chromosomes fitted simultaneously.

Journal of Dairy Science Genome Research, 17 4pp. PAX3 is a transcription factor known to be involved in melanogenesis [35].

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Qianqian Zhang: Towards Cattle Precision Breeding Using Next Generation Sequencing

Paisch Journal of Comparative Medicine. Candidate gene polymorphisms were genotyped in these animals, and the genotypes of the remaining animals of the study population were inferred using the EM algorithm implemented in fastPHASE.

I also want to express my gratitude to Dr. SNPs were considered as significantly associated on a genome-wide level for P values below 7. The association signal on chromosome 21 diissertation apparent only when population structure was corrected for. Thus, the two QTL might primarily affect fetal growth. For the high-density dataset, 0.

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There are also reports on QTL for postnatally measured growth traits in Wagyu [34],[35] and a Jersey — Limousin cross [36], indirectly supporting our suggestive evidence for a secondary pCE QTL on chromosome Hayes B, Goddard ME The distribution of the effects of genes diissertation quantitative traits in livestock. The methods used in exploiting the use of whole genome sequence variants can be useful pauech studying other livestock species.

Mapping genomic regions underlying quantitative traits The main objective of QTL mapping in livestock populations was the identification of suitable markers to improve economically relevant traits via marker-assisted selection MAS [12].

dissertation hubert pausch

However, an apparent association signal was observed on chromosome 14 P: Orange dots represent significantly associated SNPs on a chromosome-wide level, red dots represent significantly associated SNPs on a genome-wide level.

BayesB [25] were shown to clearly outperform ‘classical’ genomic prediction using GBLUP for traits which are controlled by large-effect genes [23],[26], [27].