MHH DISSERTATION 2012

The scientific aim is to develop new diagnosis possibilities and therapies for vascular diseases, which are based on microRNAs. Sandor Batkai was awarded a three year Marie Curie Grant by the European Commission to support his professional reintegration to Germany. Recently, circulating extracellular miRNAs have emerged as regulators of cell-cell-communication and indicate a role in the mediation of paracrine signaling. As transforming growth factor TGF -beta is linked to abnormal vessel function and can mediate impairment of endothelial angiogenic responses we studied its effects on microRNAs expression and identified miRa-3p, along with other members of the miR family, to be strongly silenced. Thomas Thum, director of the institute.

Clinical data regarding platelet miRNA expression patterns and their interaction with platelet mRNA in diabetes is scarce. Luciferase reporter assays validated mimecan as a bona fide miR target. The current list of Highly Cited Researchers https: The new TRAIN Project is specifically focusing on drugs that might limit the pathological heart growth caused by myocardial infarction or high blood pressure. The researchers have published their findings in the journal Science Translational Medicine February 17 th , Functionally, miR overexpression induced cellular senescence and promoted migratory activity of cardiac fibroblasts.

mhh dissertation 2012

Blocking of endothelial miR limited myocardial infarct size of mice via prevention of endothelial apoptosis and enhancement of vascularity, which led to preserved cardiac function and survival.

We assessed the diagnostic and prognostic value of all major cardiomyocyte-enriched microRNAs in the context of clinical variables and a sensitive myonecrosis biomarker in a large ACS cohort. LIPCAR levels identified patients developing cardiac remodeling and indicate a strong association with cardiovascular mortality.

mhh dissertation 2012

September New therapies for conditions such as cardiac hypertrophy and heart failure are needed and may be developed as a result of a better understanding of the tight regulation of gene transcription in heart muscle cells. Locked nucleic acid-mediated miR silencing ameliorated cardiac fibrosis development in vivo. The findings have been published dissergation the Journal of the American Society of Nephrology and can be found here.

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Fabian Kreutzer presented in the AWARD session, sponsored by NovoNordisk, among the 5 best abstracts in translational dissertatino shown together with the other junior scientists and with Prof. May We identified miR in the heart to be regulated by osteopontin OPNan important pro-fibrotic cytokine. With more than active participants the meeting was the so far largest meeting of the Working Groups and a great success. During autophagy, the cells break down and reuse mhy that are no longer needed.

Ariana Foinquinos won the 2 nd prize in the Young Investigator Award session for her presentation on 20112 Pharmacological microRNA modulation for the treatment of heart failure.

mhh dissertation 2012

In cardiovascular disease the diagnostic utility of circulating lncRNAs has not been investigated so far. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms dissrrtation cardiac angiogenesis are mechanistically not well understood.

Our observation that a microRNA in endothelial cells affects downstream epigenetic pathways leading to impaired angiogenic activity opens new avenues for using miRNAs as epigenetic modifiers to develop of novel vascular therapeutic strategies. More details about the Foundation can be found here: Transient overexpression of miR alone induced apoptosis and altered functional parameters in these cells, whereas silencing of miR ameliorated apoptotic responses and rescued functional parameters in hypoxic conditions.

This study paves a way for future miRNA based therapeutics for treatment of heart failure patients.

Impaired wound healing 0212 a major cause of lower extremity amputations in diabetic subjects. Role of long non-coding RNAs as potential Biomarkers in heart disease.

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Recent Events

MayHaigerloch, Germany — 6. April Physiological aging and senescence are associated to progressive disserttaion in most physiological functions, reduced response to stress, loss of viability and increased susceptibility to various diseases.

Arterioscler Thromb Vasc Biol. July The Physiological Society invited Dr. TGF-beta is particularly involved in cardiac fibrosis partly by stimulation of endothelial-to-mesenchymal transition. The project is expected to start on April 1st MicroRNAbased therapeutic treatment of myocardial infarction.

Katharina Schimmel at DGM second left. It was never dissedtation in humans before, but already known from newborn mice.

COST actions do not support individual research projects but rather networking activities, like congresses and exchange of scientists. MicroRNAs regulating senescence and fibrosis in the aging heart. This recently published study showed the potential use of circulating lncRNAs in plasma as prognostic biomarkers for heart failure.

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The paper has been published in Circulation Research and can be found here: Luciferase reporter assays validated mimecan as a bona fide miR target. Overexpression of this transcript induced pathological heart growth, while antisense-oligonucleotide disertation blockage of the lncRNAs activity prevented and attenuated hypertrophic cardiac remodeling, opening new avenues for therapeutical applications and strategies.

The researchers have published their findings in the journal Science Translational Medicine February 17 th Both, miR and its target mimecan were co- expressed in cardiac fibroblasts and smooth muscle cells.

Publication highlights the protective role of Quaking in preventing doxorubicin-induced cardiotoxicity.