SOLID SMEDDS THESIS

Effect of FK loading on physical stability of microemulsions was studied using optimized composition i. They also minimize the mucosal irritation due to the contact between the drug and the gut wall. Cosurfactant S mix 1 1: Review, Journal of Pharmacy Research , 3 1 , 6. This study was a Pharm. Improved absorption can be achieved by use of delivery systems, which can enhance drug dissolution from its dosage form and maintains drug in dissolved state in GI fluids. Effect of FK Loading Effect of FK loading on physical stability of microemulsions was studied using optimized composition i.

Thus, it was thought that, combination of above factors may result in an increase in rate and extent of absorption of FK leading to its improved therapeutic efficacy over commercial formulation. Then solidified it with incorporating liquid SNEDDS into spherical pellets produced by the extrusion-spheronization technique. These advantages of FK coupled with its long-term tolerability led to improved graft and patient survival indicating its clinical potential 3. Upload from Desktop Single File Upload. Find articles by Mohammadreza Abbaspour.

solid smedds thesis

Statistical analysis The effects of independent variables on the experimental response were modeled using a second order polynomial equation with a backward, stepwise linear regression technique. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. This may explained by emulsifying effect of solid components in the formulation.

Material 1 2 Ethanol 3 0.

THESIS PRESENTATION |authorSTREAM

The developed formulations were characterized by determination of their morphology, size, friability, in-vitro drug release, disintegrating properties, and emulsion droplet size analysis.

It has been shown that finely divided solid particles can be used as emulsifying agents and emulsion stabilizer.

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solid smedds thesis

Then solidified it with incorporating liquid SNEDDS into spherical pellets produced by the extrusion-spheronization technique. Formulation formed transparent, gel like intermediate structure prior xmedds dispersing completely but could form microemulsion. Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats.

Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

Results of in vivo studies are shown in Fig. Comparative pharmacodynamic evaluation was investigated in terms of lipid-lowering efficacy. The pellets have improved appearance with fine pharmaceutical elegance, they can decrease the risk of dose dumping and local mucosal irritation, avoid powder dusting in the pharmaceutical industries, also their larger surface area enables better distribution in case of immediate release products.

Handbook of pharmaceutical excipients. The effect of oil content, pH of aqueous phase, dilution, and incorporation of drug on mean globule size of resulting microemulsions was studied. smwdds

Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

Freshly prepared double distilled water was used. Drug Incorporation can have significant influence on mean globule size and needs to be investigated 22 A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. Improved absorption can be achieved emedds use of delivery systems, which can enhance drug dissolution from its dosage form and maintains drug in dissolved state in GI fluids.

Therefore, due to larger microemulsification area and greater capacity for oil incorporation, which is desirable to improve drug loading, Cremophor EL-Carbitol-Capmul MCM C8 system was selected for further studies.

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This increases molecular volume and affects penetration at interface. The objective of present investigation was to formulate self-microemulsifying drug delivery systems SMEDDS of tacrolimus FKa poorly water soluble immunosuppressant that exhibits low and erratic bioavailability.

In this study the mechanical strength of pellets was not significantly affected by studied factors. Formulation exhibits poor emulsification with coalescence of oil droplets.

Clinical pharmacokinetics and pharmacodynamics of FK in solid organ smecds. Therefore, current scenario demands a need for a delivery strategy that can improve its therapeutic efficacy. The oral dosage form of FK Based on previous studies, 18 a self-emulsifying system was prepared containing a fixed proportion of loratadin 0. Effect of FK loading on mean globule size is shown in Fig.

As it is important to achieve optimum drug loading 1113solubility study was aimed to identify suitable SMEDDS components that possess good solubilizing capacity for selected drug. Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions. The mean dissolution time MDT was used to compare the release profiles easily, Table 3. In vitro dissolution profile of different pellets formulation. Analytical methods used for calibration UV spectroscopy Sr.

Open in a separate window. Establishment of new preparation method for solid dispersion formulation of tacrolimus.