Chronic stress, the HPA axis, and physical and mental health disparities over the life course. This article examines the key challenges in and progress of behavioral intervention research, the trajectory of introducing a new behavioral intervention with potential for implementation, and key considerations in developing an intervention protocol. A biobehavioral home-based intervention and the well-being of patients with dementia and their caregivers: Thus, mechanisms for infusing new evidence to enhance the existing intervention need consideration. Each of these considerations should be informed by theory, best evidence, practice guidelines, and clinical know-how and knowledge of the implementation goal and site.

Although interventions needed to improve the public’s health are complex and funding lags behind, introducing new interventions remains a critical and most worthy pursuit. An active intervention, however, should not include any active ingredients being tested in the treatment group. Health behavior and health education: First, the epidemiological record may be incomplete or inadequate to substantiate the scope of a health problem. Integrating cost analyses early on and using hybrid models also hold promise for closing the research—practice gap. In the latter case, please turn on Javascript support in your web browser and reload this page.

Demonstrating efficacy is only the first requirement on the long road to introducing an intervention into standard care.

tailored biobehavioral interventions a literature review and synthesis

Behavior, lifestyle, and the social and physical environment are the primary contributors to longevity, health, well-being, and quality of life Buetner, Rethinking the efficacy-to-effectiveness transition.

Building the health care workforce.

Understanding and assessing the barriers to optimal health care. The Issue Is—How do we change practice when we have the evidence?

Tailored biobehavioral interventions: a literature review and synthesis.

Consideration litreature cost associated with training in using intervention and its delivery. Nevertheless, strategies to shorten the developmental trajectory and enhance implementation need to be evaluated to establish evidence that they indeed improve knowledge transfer. Health behavior and health synthessis Combining elements of clinical effectiveness and implementation research to enhance public health impact. In addition to the funding sources discussed above, activities for this phase can be supported through the NIH R21 mechanism.


New hybrid models that blend test phases and involve a team approach consisting of stakeholders and end users up front in developing and testing interventions may shorten the timeframe and enhance adoption.

National Geographic Press; Enhancing the quality of life of dementia caregivers from different ethnic or racial groups: Also, a modified ITT can be used in which data only of participants available at the follow-up are used, regardless of their level of intervention participation. Knowledge generated from activities in this phase can advance a working intervention prototype and treatment manual.

Race and unhealthy behaviors: Using principles of community-based participatory research, involvement of agency personnel, clinicians, or community members may facilitate development of interventions that are more responsive and implementation ready. A competitive application for an efficacy trial must be supported by pilot test results, demonstration of feasibility, expected effect size, treatment manuals detailing treatment and control group protocols, tested recruitment and enrollment procedures, and a strong theory base and hypotheses.

Yet another approach is involvement of stakeholders and end users as research team members in early phases. Nevertheless, although these interventions have been shown to be effective, they are mostly out of reach to the public, primarily because of the complexities of workforce preparatory needs and the fiscal constraints of care settings.


Phase 1 testing involves identifying and evaluating intervention components and determining acceptability, feasibility, and safety.

Introducing a New Intervention: An Overview of Research Phases and Common Challenges

ITT may require that interpolation methodologies be applied because behavioral trials always experience attrition. Open in a separate window. Why behavioral and environmental interventions are needed to improve health at lower cost.

Description of the Beat the Blues randomized trial and intervention costs. Given the elongated process of building and testing a behavioral intervention as shown in the six test phases, recent efforts have been directed at developing hybrid models to accelerate the sunthesis process Curran et al.

Tailored biobehavioral interventions: a literature review and synthesis.

In this phase, case studies, pre—post study designs, or focus groups, or a combination of these methodologies, can help define and refine intervention delivery characteristics e.

An opportunity for occupational therapy. Also, intramural support through pilot study mechanisms and foundation support are feasible funding alternatives. An organizing framework for translation in public health: Introducing a new biobehaviorall intervention is an important and exciting endeavor but is not without challenges.

Key Considerations in Designing an Intervention Table 1 outlines domains and specific elements to consider in constructing an intervention. An essential question in this phase is, Why would the intervention work? Department of Interventios and Human Services.

tailored biobehavioral interventions a literature review and synthesis